General Information |
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Product |
Phospho-PDE4D PKA site (S190) Peptide |
Description |
Antigenic Blocking Peptide Phosphorylated Phosphodiesterase 4D PKA site (S190) |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide selective for PDE4D PKA site taken within amino acid region 50-100 on human PDE4D8 protein. Phosphorylated Serine 190 residue. Derived around the PKA phosphorylation site of serine 190:
R-E-SP-F-L |
Accession # |
NCBI: NP_001184148.1 |
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Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
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Competition/Depletion assay |
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Uniprot # |
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Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
Molecular Function |
Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding |
Subcellular Location |
Apical cell membrane, Cytoplasm, Membrane |
Expression |
Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. |
Structure |
Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). |
Alternative Nomenclature |
cAMP specific 3',5' cyclic phosphodiesterase 4D antibody DKFZp686M11213 antibody 5''-cyclic phosphodiesterase 4D antibody cAMP specific 3' 5' cyclic phosphodiesterase 4D antibody cAMP specific phosphodiesterase 4D antibody cAMP specific phosphodiesterase PDE4D antibody cAMP specific phosphodiesterase PDE4D6 antibody cAMP-specific 3'' antibody cyclic AMP phosphodiesterase antibody DPDE3 antibody Dunce like phosphodiesterase E3 antibody FLJ97311 antibody HSPDE4D antibody PDE43 antibody PDE4DN2 antibody Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3) antibody Phosphodiesterase 4D cAMP specific (phosphodiesterase E3 dunce homolog Drosophila) antibody Phosphodiesterase 4D cAMP specific antibody Phosphodiesterase E3 dunce homolog Drosophila antibody STRK 1 antibody |
Protein information supplied by UniProt
FabGennix Phospho-PDE4D Antibody has been used in 6 Publications |
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Zamarbide, Marta, et al. "Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability." Biological psychiatry 85.9 (2019): PMID030732858 |
Western Blot; Mouse |
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Western Blot; Mouse |
Fu, Qin, et al. "A Long Lasting β1 Adrenergic Receptor Stimulation of cAMP/Protein Kinase A (PKA) Signal in Cardiac Myocytes." Journal of Biological Chemistry 289.21 (2014): 14771-14781. PMID24713698
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Western Blot; Mouse |
Liu, Shubai et al. “Phosphodiesterases Coordinate cAMP Propagation Induced by Two Stimulatory G Protein-Coupled Receptors in Hearts.”Proceedings of the National Academy of Sciences of the United States of America 109.17 (2012): 6578–6583. PMC3340097
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Western Blot; Mouse |
Murthy, Karnam S., and Wimolpak Sriwai. "Stimulatory phosphorylation of cAMP-specific PDE4D5 by contractile agonists is mediated by PKC-dependent inactivation of protein phosphatase 2A." American Journal of Physiology-Gastrointestinal and Liver Physiology 294.1 (2008): G327-G335. PMID18006600
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Western Blot; Human
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Zhu, Bing, et al. "Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells." Biochemical pharmacology 68.3 (2004): 479-491. PMID15242814
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Western Blot; Human |
Publishing research using PPD4-440AP? Please let us know, we can cite the reference in this datasheet.
Western Blot; Human
Western Blot; Mouse
Product | Note | Status | Price | |
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PPD4-440AP | |||
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PPD4.440-FITC | |||
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PPD4.440-BIOTIN | |||
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PC-PPD4.440 | |||
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