General Information |
|
Product |
Phospho-PDE7A Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Phosphorylated Synthetic cyclic peptide common to all PDE7A variants |
Specificity |
This antibody is specific for PDE7A variants and will not cross-react with PDE7B or other PDE family members. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.50-0.75 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunoprecipitation |
1:250 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. |
Molecular Function |
Hydrolase, 3', 5' -cyclic-AMP phosphodiesterase activity |
Subcellular Location |
Cytoplasm |
Expression |
PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart. Developmentally regulated. PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development. It persists strongly only in adult skeletal muscle. |
Structure |
Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain. |
Alternative Nomenclature |
HCP 1 antibody P2A antibody PDE 7 antibody PDE 7A antibody PDE1/PDE2 yeast human complement of antibody PDE7 antibody PDE71 antibody Phosphodiesterase 7A antibody Phosphodiesterase isozyme 7 antibody Rolipram insensitive phosphodiesterase type 7 antibody TM22 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
PPD7A-140AP | |||
|
PPD7A-FITC | |||
|
P-PPD7A | |||
|
PC-PPD7A | |||
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