General Information
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Product
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RASGRF2 Positive Control
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Description
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Western Blot Positive Control Ras-specific guanine nucleotide-releasing factor 2
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Verified Applications
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WB
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Immunogen
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Purified Protein
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Physical Properties
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Quantity
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5 Applications
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Volume
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Inquire
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Form
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Western Blot Positive Control
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Storage
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-20⁰C for long term storage
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Application Protocol
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Western Blot
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1:500
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Protein
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Uniprot #
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O14827
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Overview
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Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation.
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Molecular Function
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Guanine-nucleotide releasing factor, Rho guayl-nucleotide exchange factor activity
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Subcellular Location
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Cytoplasm, Cell membrane; Peripheral membrane protein, Endoplasmic reticulum membrane; Peripheral membrane protein
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Expression
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Widely expressed with higher expression in the brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung.
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Structure
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Homooligomer and heterooligomer with RASGRF1. Interacts with Ras and RAC1. Interacts in a calcium-dependent manner with calmodulin.
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Alternative Nomenclature
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GRF2 antibody
Ras guanine nucleotide exchange factor 2 antibody
Ras-GRF2 antibody
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