General Information |
|
Product |
Topoisomerase II alpha Antibody FITC |
Description |
FITC-Conjugated DNA topoisomerase (ATP-hydrolysing) Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 1220-1270 on human DNA topoisomerase (ATP-hydrolysing) protein. |
Accession # |
GenBank: CAA09762.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.54-0.57 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation | 1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. |
Molecular Function |
Isomerase, Topoisomerase, ATP binding |
Subcellular Location |
Cytoplasm, Nucleus |
Structure |
Homodimer. Interacts with COPS5. Interacts with RECQL5; this stimulates DNA decatenation. Interacts with SETMAR; stimulates the topoisomerase activity. |
Alternative Nomenclature |
alpha isozyme antibody ATP hydrolyzing DNA topoisomerase II alfa antibody DNA gyrase antibody DNA topoisomerase 2 alpha antibody DNA topoisomerase II 170 kD antibody DNA topoisomerase II alpha isozyme antibody TOP2 antibody TOP2A antibody Topoisomerase DNA II alpha 170kDa antibody TP2A antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
TOPO2A-201AP | |||
|
P-TOPO2A | |||
|
TOPO2A-BIOTIN | |||
|
PC-TOPO2A | |||
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