General Information
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Product
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DDIT3 Antibody FITC-Conjugated
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Description
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FITC-Conjugated DNA damage-inducible transcript 3 protein Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 60-160 on human GADD153 protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.57-0.68 µg/µl in antibody stabilization buffer
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Form
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FITC-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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P35638
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Overview
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Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes.
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Molecular Function
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Activator, Repressor, DNA binding
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Subcellular Location
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Cytoplasm, Nucleus
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Structure
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Heterodimer. Interacts with TCF7L2/TCF4, EP300/P300, HDAC1, HDAC5 and HDAC6. Interacts with TRIB3 which blocks its association with EP300/P300. Interacts with FOXO3, CEBPB and ATF4.
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Alternative Nomenclature
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C/EBP homologous protein antibody
C/EBP zeta antibody
CCAAT/enhancer binding protein homologous protein antibody
CEBPZ antibody
CHOP 10 antibody
DDIT3 antibody
DNA Damage Inducible Transcript 3 antibody
GADD153 antibody
Growth Arrest and DNA Damage Inducible Protein 153 antibody
MGC4154 antibody
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