General Information
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Product
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KDM4C / GASC1 / JMJD2C Positive Control
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Description
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Western Blot Positive Control JmjC domain-containing histone demethylation protein 3C
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Verified Applications
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WB
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Immunogen
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Purfied protein.
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Physical Properties
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Quantity
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5 Applications
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Volume
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Inquire
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Form
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Western Blot Positive Control
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Storage
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-20⁰C for long term storage
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Application Protocol
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Western Blot
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1:2,500-1:5,000
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Protein
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Uniprot #
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Q9H3R0
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Overview
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Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
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Molecular Function
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androgen receptor binding
chromatin binding
enzyme binding
histone demethylase activity
histone demethylase activity (H3-K36 specific)
histone demethylase activity (H3-K9 specific)
zinc ion binding
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Subcellular Location
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Nucleus
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Expression
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Overexpressed in several esophageal squamous cell carcinomas (ESCs).
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Structure
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The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails.
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Alternative Nomenclature
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bA146B14.1 antibody
GASC 1 protein antibody
Gene amplified in squamous cell carcinoma 1 protein antibody
JHDM3C antibody
JMJD2C antibody
Jumonji domain containing 2C antibody
Kdm4c antibody
Lysine demethylase 4C antibody
TDRD14C antibody
Tudor domain containing 14C antibody
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