General Information
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Product
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MAPK12 Peptide
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Description
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Antigenic Blocking Peptide Mitogen-activated protein kinase 12 Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 310-360 on human Mitogen-activated protein kinase 12.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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P53778
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Overview
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Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.
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Molecular Function
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Kinase, Serine/threonine-protein kinase, Transferase
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Subcellular Location
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Cytoplasm, Mitochondrion, Nucleus
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Expression
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Highly expressed in skeletal muscle and heart.
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Structure
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The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
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Alternative Nomenclature
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ERK 3 antibody
ERK 5 antibody
ERK 6 antibody=Extracellular signal-regulated kinase 6 antibody
MAP kinase 12 antibody
MAP kinase p38 gamma antibody
Mitogen Activated Protein Kinase 12 antibody
Mitogen activated protein kinase 3 antibody
P38 GAMMA antibody
PRKM12 antibody
SAPK 3 antibody
Stress Activated Protein Kinase 3 antibody
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