General Information
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Product
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ORP150 Peptide
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Description
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Antigenic Blocking Peptide Hypoxia up regulated 1
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 950-999 on human Hypoxia up regulated 1.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q9Y4L1
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Overview
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Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
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Molecular Function
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ATP binding; chaperone binding
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Subcellular Location
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Endoplasmic reticulum lumen
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Expression
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Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.
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Structure
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Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Belongs to the heat shock protein 70 family.
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Alternative Nomenclature
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150 kDa oxygen regulated protein antibody
170 kDa glucose regulated protein antibody
DKFZp686N08236 antibody
FLJ94899 antibody
FLJ97572 antibody
glucose regulated protein 170 antibody
Grp 170 antibody
Grp170 antibody
HSP 12A antibody
HSP12A antibody
Hyou1 antibody
Hypoxia up regulated 1 antibody
Orp 150 antibody
Orp150 antibody
oxygen regulated protein (150kD) antibody
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