General Information
|
|
Product
|
TREX1 Antibody BIOTIN-Conjugated
|
Description
|
BIOTIN-Conjugated Three-prime repair exonuclease 1 Antibody
|
Verified Applications
|
ELISA, IHC, IF, IP, WB
|
Host
|
Rabbit
|
Species Cross Reactivity
|
Human, Mouse, Rat
|
Immunogen
|
Synthetic peptide taken within amino acid region 220-245 on human TREX1 protein.
|
Specificity |
This antibody is specific for TREX1. This antibody will not detect TREX2. |
Physical Properties
|
|
Quantity
|
100 µg
|
Volume
|
200 µl
|
Concentration
|
0.55-0.75 µg/µl in antibody stabilization buffer
|
Form
|
BIOTIN-Conjugated
|
Clonality
|
Polyclonal
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
ELISA
|
1:10,000
|
Immunofluorescence |
1:100 |
Immunohistochemistry |
1:50-1:100 |
Immunoprecipitation
|
1:200
|
Western Blot
|
1:500
|
Protein
|
Uniprot #
|
Q9NSU2
|
Overview
|
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements.
|
Molecular Function
|
Exonucleus, Hydrolase, Nuclease
|
Subcellular Location
|
Nucleus, Cytoplasm, Endoplasmic reticulum membrane; Peripheral membrane protein
|
Expression
|
Detected in thymus, spleen, liver, brain, heart, small intestine and colon.
|
Structure
|
Homodimer. Interacts (via proline-rich region) with TCERG1/CA150 (via the second WW domain). Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1.
|
Alternative Nomenclature
|
3' 5' exonuclease TREX1 antibody
3' repair exonuclease 1 antibody
AGS1 antibody
AGS5 antibody
CRV antibody
Deoxyribonuclease III, dnaQ/mutD (E. coli) like antibody
DKFZp434J0310 antibody
DNase III antibody
DRN3 antibody
HERNS antibody
Three prime repair exonuclease 1 antibody
TREX1 antibody
|
|
|