Ephrin Receptor A1 Positive Control

General Information

Product

Ephrin Receptor A1 Positive Control

Description

Western Blot Positive Control Ephrin type-A receptor 1 Antibody

Verified Applications

WB

Immunogen

Purified Protein

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

P21709

Overview

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Molecular Function

ATP binding; protein kinase activity; protein kinase binding; transmembrane-ephrin receptor activity

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Overexpressed in several carcinomas.

Structure

Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA

Alternative Nomenclature

EPH antibody

EPH receptor A1 antibody

Eph tyrosine kinase 1 antibody

EphA1 antibody

Ephrin receptor Eph A1 antibody

Ephrin type-A receptor 1 antibody

EPHT 1 antibody

Erythropoietin producing hepatoma amplified sequence antibody

Esk antibody

Esk antibody

hEpha1 antibody

MGC163163 antibody

Oncogene EPH antibody

Soluble EPHA1 variant 1 antibody

Soluble EPHA1 variant 2 antibody

Tyrosine protein kinase receptor EPH antibody