General Information
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Product
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DAPK2 Positive Control
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Description
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Western Blot Positive Control Death-associated protein kinase 2 Antibody
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Verified Applications
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WB
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Physical Properties
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Quantity
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5 Applications
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Volume
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Inquire
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Form
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Western Blot Positive Control
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Storage
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-20⁰C for long term storage
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Application Protocol
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Western Blot
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1:2,500-1:5,000
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Protein
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Uniprot #
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Q8VDF3
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Overview
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Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals.
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Molecular Function
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ATP binding
calmodulin binding
identical protein binding
protein serine/threonine kinase activity
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Subcellular Location
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Cytoplasm
autophagosome lumen
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Expression
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Expressed in peritubular interstitial cells of the renal cortex (PubMed:24906443). Isoform 1 is found in the adult brain while isoform 2 is expressed in brains of embryos and young mice (at protein level) (PubMed:21408167).
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Structure
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The autoinhibitory domain sterically blocks the substrate peptide-binding site by making both hydrophobic and electrostatic contacts with the kinase core.
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Alternative Nomenclature
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DAK2 antibody
DAP kinase 2 antibody
DAP kinase related protein 1 antibody
DAP kinase related protein 1 beta isoform antibody
DAP-kinase-related protein 1 antibody
DAPK2 antibody
Death associated protein kinase 2 antibody
DRP 1 antibody
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