General Information
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Product
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JMJD2D Antibody Affinity Purified
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Description
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Affinity Purified Jumonji domain-containing protein 2D Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Monkey
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Immunogen
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Synthetic peptide taken within amino acid region 340-390 on human Jumonji domain containg 2D protein.
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Accession #
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GenBank: AAI19011.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.55-0.75 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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Q6B0I6
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Overview
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Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
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Molecular Function
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Chromatin regulator, Dioxygenase, Oxidoreductase
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Subcellular Location
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Nucleus
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Structure
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Belongs to the JHDM3 histone demethylase family.
Contains 1 JmjC domain.
Contains 1 JmjN domain.
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Alternative Nomenclature
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JHD3D antibody
JHDM3D antibody
JmjC domain-containing histone demethylation protein 3D antibody
Jumonji domain-containing protein 2D antibody
Kdm4d antibody
Lysine-specific demethylase 4D antibody
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