General Information |
|
Product |
RIP140 Peptide |
Description |
Antigenic Blocking Peptide Receptor interacting protein 140 C-epitope |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid region 1050-2000 corresponding to the C terminal domain of RIP140. |
Accession # |
GenBank: AF053062.1 |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Determinant |
C-epitope |
Storage |
-20⁰C for long term storage |
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|
Competition/Depletion assay |
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Uniprot # |
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Overview |
Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. |
Molecular Function |
Core promoter sequence-specific DNA binding; Estrogen Receptor binding; Glucocortioid receptor binding; Histone deacetylase binding; Nuclear hormone receptor binding; Receptor binding; Transcription coactivator/corepressor activity. |
Subcellular Location |
Nucleus |
Expression |
Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments. |
Structure |
Contains at least 4 autonomous repression domains (RD1-4). Contains 9 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which have different affinities for nuclear receptors. The Ligand-dependent nuclear receptor binding region is required for ligand-dependent interaction with RAAR and RXRB homo- and heterodimers, for the corepressor activity, and for the formation of an HDAC3 complex with RARA/RXRB. |
Alternative Nomenclature |
NRIP 1 antibody Nuclear factor RIP 140 antibody Nuclear receptor interacting protein 1 antibody Receptor-interacting protein 140 antibody RIP140 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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RIP140-121AP | |||
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RIP140.121-FITC | |||
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RIP140.121-BIOTIN | |||
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PC-RIP140 | |||
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