Phospho-KIRREL Blocking Peptide

General Information

Product

Phospho-KIRREL Peptide

Description

Antigenic Blocking Peptide kin of IRRE-like protein 1 Antibody C-epitope

Verified Applications

Immunocompetition, Immunodepletion

Peptide Description

Phosphorylated synthetic peptide with phospo tyrosine 737 and 738 on mouse Kin of IRRE-like protein 1.

Accession #

NCBI:  NP_060710.3

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q80W68

Overview

Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.

Molecular Function

Myosin Binding

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.

Structure

Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylated with GRB2.

Alternative Nomenclature

FLJ10845 antibody

Kin of IRRE like protein 1 antibody

Kirrel antibody

NEPH1 antibody

Nephrin like protein 1 antibody