Overview
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Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Inhibits KAT6B-dependent transcriptional activation.
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Alternative Nomenclature
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Acute myeloid leukemia 3 protein antibody
Alpha subunit 1 antibody
AML3 antibody
CBF alpha 1 antibody
CBFA1 antibody
CCD1 antibody
Cleidocranial dysplasia 1 antibody
Core binding factor runt domain alpha subunit 1 antibody
Core binding factor subunit alpha 1 antibody
Oncogene AML 3 antibody
OSF 2 antibody
Osteoblast specific transcription factor 2 antibody
PEBP2 alpha A antibody
PEBP2A1 antibody
PEBP2A2 antibody
Polyomavirus enhancer-binding protein 2 alpha A subunit antibody
Runt domain antibody
Runt related transcription factor 2 antibody SL3 3 enhancer factor 1 alpha A subunit antibody
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