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General Information
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Product
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MeCP2 isoform 1 Peptide
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Description
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Antigenic Blocking Peptide Methyl-CpG-binding protein 2 Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 1-50 on mouse methyl-CpG-binding protein 2 isoform 1.
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Accession #
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NCBI: NP_004983
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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P51608
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Overview
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Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
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Molecular Function
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Chromatin binding, DNA binding, mRNA binding, double-stranded methylated DNA binding, poly(A) RNA binding, siRNA binding
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Subcellular Location
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Nucleus (Note: Colocalized with methyl-CpG in the genome)
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Expression
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Interacts with FNBP3. Interacts with CDKL5 (PubMed:15917271). Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells. Interacts with NCOR2.
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Structure
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Present in all adult somatic tissues tested.
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Alternative Nomenclature
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AUTSX 3 antibody
Mbd5 antibody
MeCP-2 protein antibody
MeCP2 antibody
Methyl CpG binding protein 2 (Rett syndrome) antibody
Methyl CpG binding protein 2 antibody
MRX 16 antibody
MRX 79 antibody
MRXS13 antibody
MRXSL antibody
PPMX antibody
RS antibody
RTS antibody
RTT antibody
WBP 10 antibody
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MeCP2 isoform 1 Antibody
MeCP2 isoform 1 Antibody BIOTIN
MeCP2 isoform 1 Antibody FITC
MeCP2 isoform 1 Positive Control
