HIPK1 Positive Control

General Information

Product

HIPK1 Antibody Positive Control

Description

Western blot positive control Homeodomain-interacting protein kinase 1 Antibody

Verified Applications

WB

Immunogen

Purified protein.

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western blot positive control

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q86Z02

Overview

Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.

Molecular Function

ATP binding

protein serine/threonine kinase activity

Subcellular Location

Nucleus

Expression

Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis.

Structure

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.

Alternative Nomenclature

Hipk 1 antibody

Homeodomain interacting protein kinase 1 antibody

Myak antibody

Nbak 2 antibody

Nuclear body associated kinase 2 antibody