General Information
|
|
Product
|
PD-L1 Antibody
|
Description
|
Affinity Purified Programmed cell death 1 ligand 1 Antibody
|
Verified Applications
|
ELISA, IHC, IP, WB
|
Host
|
Rabbit
|
Species Cross Reactivity
|
Human, Monkey
Predicted: Mouse, Rat
|
Immunogen
|
Synthetic peptide taken within amino acid reigon 80-130 on human Progammed cell death 1 ligand 1 protein.
|
Accession #
|
NCBI: NP_054862
|
Physical Properties
|
|
Quantity
|
100 µg
|
Volume
|
200 µl
|
Concentration
|
0.5 µg/µl in antibody stabilization buffer
|
Immunoglobulin
|
IgG
|
Form
|
Affinity Purified
|
Purification Method
|
Immobilized antigen affinity chromatography
|
Clonality
|
Polyclonal
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
ELISA
|
1:10,000
|
Immunohistochemistry |
1:50-1:100 |
Immunoprecipitation
|
1:150
|
Western Blot
|
1:500
|
Protein
|
Uniprot #
|
Q9NZQ7
|
Overview
|
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
|
Molecular Function
|
Receptor
|
Subcellular Location
|
Isoform 1 : Cell membrane; Single-pass type I membrane protein
Isoform 2 : Endomembrane system; Single-pass type I membrane protein
|
Expression
|
Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
|
Structure
|
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
|
Alternative Nomenclature
|
B7 H antibody
B7 homolog 1 antibody
CD 274 antibody
PD L1 antibody
PDCD1 ligand 1 antibody
PDCD1L1 antibody
PDCD1LG1 antibody
PDL 1 antibody
Programmed death ligand 1 antibody
RGD1566211 antibody
|
|
|