General Information |
|
Product |
AGE Antibody FITC-Conjugated |
Description |
FITC-Conjugated Advance Glycated Endproduct Antibody |
Verified Applications |
ELISA, WB |
Host |
Rabbit |
Species Cross Reactivity |
Bovine, Human, Monkey, Panda |
Immunogen |
Purified glycated ribonuclease corresponding to AGE. Glycated ribonuclease (RNase) prepared by incubating RNase with glucose at 37⁰C for several months. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.55 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Western Blot |
1:500 |
|
|
Overview |
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. |
Molecular Function |
Inflammatory Response |
Subcellular Location |
Isoform 1 : Cell membrane; Single-pass type I membrane protein Isoform 2 : Secreted Isoform 10 : Cell membrane 1 Publication; Single-pass type I membrane protein |
Expression |
Endothelial cells. |
Structure |
Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked. |
Alternative Nomenclature |
Advanced glycation end products antibody AGEs antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
AGE-101AP | |||
|
P-AGE | |||
|
AGE-BIOTIN | |||
|
PC-AGE | |||
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