General Information
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Product
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PREX2 Antibody Affinity Purified
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Description
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Affinity Purified PtdIns(3,4,5)-dependent Rac exchanger 2a Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse
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Immunogen
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Synthetic peptide taken within amino acid region 720-900 on PREX2 protein.
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Accession #
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GenBank: DAA05334.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.65 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:20,000-1:50,000
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ELISA
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1:20,000-1:50,000
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Western Blot
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1:500-1:750
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Protein
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Uniprot #
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Q70Z35
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Overview
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Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
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Molecular Function
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Rac GTPase activator activity, Rac guanyl-nucleotide exchange factor activity
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Expression
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Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart.
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Alternative Nomenclature
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4 antibody
5)-dependent Rac exchanger 2 antibody
5-trisphosphate-dependent Rac exchanger 2 protein antibody
DEP domain-containing protein 2 antibody
DEP.2 antibody
Phosphatidylinositol 3 antibody
PtdIns(3,4,5)-dependent Rac exchanger 2 antibody
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