Presenilin 2 Positive Control

General Information

Product

Presenilin 2 Antibody Western Blot Positive Control

Description

Western Blot Positive Control Presenilin-2 isoform 1 Antibody N-epitope

Verified Applications

WB

Immunogen

Purified Protein

Accession #

NCBI:  NP_036618

Physical Properties

Quantity

5 Applications

Volume

Inquire

Form

Western Blot Positive Control

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

P49810

Overview

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane.

Molecular Function

Hydrolase, Protease, aspartic-type endopeptidase activity

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein

Expression

Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.

Structure

Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase a

Alternative Nomenclature

AD 3LP antibody

AD 4 antibody

AD 5 antibody

Alzheimer disease 4 antibody

CMD1V antibody

E5 1 antibody

Presenilin 2 (Alzheimer disease 4) antibody

PS2 antibody

PSEN 2 antibody

STM2 antibody