General Information
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Product
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STING / TMEM173 Antibody
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Description
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Affinity Purified Stimulator of interferon genes protein isoform 1 Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide corresponding to amino acid region 332-342. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to a carrier protein using hetero bifunctional cross linker.
Sequence:
SFSLLSSQEVLRHLLRQEEKEEVT
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Accession #
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NCBI: NP_938023
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.57 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunoprecipitation |
1:200 |
Western Blot
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1:500
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Protein
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Uniprot #
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86WV6
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Overview
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Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm.
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Molecular Function
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cyclic-di-GMP binding, cyclic-GMP-AMP binding, identical protein binding
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Subcellular Location
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Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm › perinuclear region. Cytoplasm
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Expression
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Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages.
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Structure
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Associates with the MHC-II complex (By similarity). Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Interacts with IFIT1 and IFIT2.
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Alternative Nomenclature
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endoplasmic reticulum IFN stimulator antibody
ERIS antibody
FLJ38577 antibody
Mediator of IRF3 activation antibody
MITA antibody
Mitochondrial mediator of IRF3 activation antibody
MPYS antibody
N terminal methionine proline tyrosine serine plasma membrane tetraspanner antibody
NET23 antibody
Stimulator of interferon genes antibody
STING antibody
Tmem173 antibody
Transmembrane protein 173 antibody
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