General Information |
|
Product |
SHANK3 Antibody |
Description |
Affinity Purified SH3 and multiple ankyrin repeat domains protein 3 Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 1600-1650 on mouse SH3 and multiple ankyrin repeat domains protein 3. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
Affinity Purified |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunohistochemistry | 1:50-1:100 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. |
Molecular Function |
GFAP/Homer scaffold activity, identical protein binding, ionotropic glutamate receptor binding, protein C-terminus binding, scaffold protein binding, SH3 domain binding, zinc ion binding |
Subcellular Location |
Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse |
Expression |
In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum. |
Structure |
Belongs to the SHANK family. Contains 6 ANK repeats. Contains 1 PDZ (DHR) domain. Contains 1 SAM (sterile alpha motif) domain. Contains 1 SH3 domain. |
Alternative Nomenclature |
AI841104 antibody DEL22q13.3 antibody KIAA1650 antibody Proline-rich synapse-associated protein 2 antibody PSAP2 antibody SH3 and multiple ankyrin repeat domains 3 antibody SH3/ankyrin domain gene 3 antibody SHAN3_HUMAN antibody Shank postsynaptic density protein antibody Shank3 antibody Shank3b antibody SPANK 2 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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SHANK3-BIOTIN | |||
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SHANK3-FITC | |||
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P-SHANK3 | |||
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PC-SHANK3 | |||
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