DKK1 Antibody
Catalog no. DKK1-101AP · Research Use Only
$285 per 100 µg. Ships within 2–3 business days from the U.S.
DKK1-101AP — affinity purified Rabbit antibody against DKK1. Validated for ELISA, WB. Reacts with Human, Mouse, Rat.
Specifications
| Catalog number | DKK1-101AP |
|---|---|
| Target | DKK1 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Conjugate | Unconjugated |
| Purity | Affinity Purified |
| Immunogen | (amino acid region 45-94 of DKK1) |
| Size | 100 µg |
| Storage | -20°C |
| UniProt | O94907 |
About this target
DKK1 Antibody (DKK1-101AP) is an affinity-purified rabbit polyclonal antibody against DKK1. It is listed for ELISA, WB and reacts with Human, Mouse, Rat. For research use only. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Subcellular location: Secreted.
Documents
Related products
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- DKK1 Blocking Peptide (P-DKK1)
- DKK1 Positive Control (PC-DKK1)
FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.