Dnmt3a Antibody
Catalog no. DNMT3A-101AP · Research Use Only
$285 per 100 µg. Ships within 2–3 business days from the U.S.
DNMT3A-101AP — affinity purified Rabbit antibody against Dnmt3a. Validated for ELISA, IP, WB. Reacts with Mouse, Rat.
Specifications
| Catalog number | DNMT3A-101AP |
|---|---|
| Target | Dnmt3a |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Reactivity | Mouse, Rat |
| Applications | ELISA, IP, WB |
| Conjugate | Unconjugated |
| Purity | Affinity Purified |
| Immunogen | Synthetic peptide corresponding to amino acids within region 100-150 on mouse DNA (cytosine-5)-methyltransferase 3A protein. |
| Size | 100 µg |
| Storage | -20°C |
| UniProt | O88508 |
About this target
Dnmt3a Antibody (DNMT3A-101AP) is an affinity-purified rabbit polyclonal antibody against Dnmt3a. It is listed for ELISA, IP, WB and reacts with Mouse, Rat. For research use only. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Subcellular location: Nucleus. Chromosome. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin.
Documents
Related products
- Dnmt3a Antibody BIOTIN (DNMT3A-BIOTIN)
- Dnmt3a Antibody FITC (DNMT3A-FITC)
- Dnmt3a Blocking Peptide (P-DNMT3A)
- Dnmt3a Positive Control (PC-DNMT3A)
FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.