Dnmt3a Blocking Peptide
Catalog no. P-DNMT3A · Research Use Only
$155 per 250 µg. Ships within 2–3 business days from the U.S.
P-DNMT3A — affinity-purified Rabbit antibody against Dnmt3a. Validated for Immunodepletion, Immunocompetition.
Specifications
| Catalog number | P-DNMT3A |
|---|---|
| Target | Dnmt3a |
| Applications | Immunodepletion, Immunocompetition |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide corresponding to amino acids within region 100-150 on mouse DNA (cytosine-5)-methyltransferase 3A protein. |
| Size | 250 µg |
| Storage | -20°C |
| UniProt | O88508 |
About this target
Dnmt3a Blocking Peptide is the antigenic blocking peptide for the Dnmt3a antibody DNMT3A-101AP. Pre-incubating the antibody with the peptide competes away specific binding, which helps confirm that a signal comes from the intended target. Supplied at 250 µg, for research use only. Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Subcellular location: Nucleus. Chromosome. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin.
Documents
Related products
- Dnmt3a Antibody (DNMT3A-101AP)
- Dnmt3a Antibody BIOTIN (DNMT3A-BIOTIN)
- Dnmt3a Antibody FITC (DNMT3A-FITC)
- Dnmt3a Positive Control (PC-DNMT3A)
FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.