IL18 Blocking Peptide
Catalog no. P-IL18 · Research Use Only
$155 per 250 µg. Ships within 2–3 business days from the U.S.
P-IL18 — affinity-purified Rabbit antibody against IL18. Validated for Immunodepletion, Immunocompetition.
Specifications
| Catalog number | P-IL18 |
|---|---|
| Target | IL18 |
| Applications | Immunodepletion, Immunocompetition |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide taken within amino acid region 144-193 on human IL18 protein. |
| Size | 250 µg |
| Storage | -20°C |
| UniProt | Q14116 |
About this target
IL18 Blocking Peptide is the antigenic blocking peptide for the IL18 antibody IL18-101AP. Pre-incubating the antibody with the peptide competes away specific binding, which helps confirm that a signal comes from the intended target. Supplied at 250 µg, for research use only. Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. Subcellular location: Cytoplasm, cytosol. Secreted. Note=The precursor is cytosolic. In response to inflammasome-activating signals, cleaved and secreted. Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
Documents
Related products
- IL18 Antibody (IL18-101AP)
- IL18 Antibody BIOTIN (IL18-112-BIOTIN)
- IL18 Antibody FITC (IL18-112-FITC)
- IL18 Antibody (IL18-112AP)
- IL18 Antibody BIOTIN (IL18-BIOTIN)
- IL18 Antibody FITC (IL18-FITC)
- IL18 Blocking Peptide (P-IL18-112)
- IL18 Positive Control (PC-IL18)
FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.