General Information
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Product
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SIGLEC10 Peptide
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Description
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Antigenic Blocking Peptide Sialic acid-binding Ig-like lectin 10 Antibody
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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Synthetic peptide taken within amino acid region 650-697 on human SIGLEC10 protein.
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Accession #
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NCBI: NP_149121.2
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q96LC7
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Overview
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Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
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Molecular Function
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carbohydrate binding
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Subcellular Location
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Isoform 1,2,3,4: cell membrane, single-pass type I membrane protein; isoform 5: secreted
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Expression
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Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.
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Alternative Nomenclature
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mSiglec G antibody,
PRO940 antibody,
Sialic acid binding Ig like lectin 10 antibody,
sialic acid binding Ig like lectin G antibody,
Sialic acid-binding Ig-like lectin 10 antibody,
Siglec G antibody,
Siglecg antibody,
SLG2 antibody
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