PMS2 Antibody
Catalog no. PMS2-201AP · Research Use Only
$285 per 100 µg. Ships within 2–3 business days from the U.S.
PMS2-201AP — affinity purified Rabbit antibody against PMS2. Validated for ELISA, IHC, IP, WB. Reacts with Human, Mouse, Rat.
Specifications
| Catalog number | PMS2-201AP |
|---|---|
| Target | PMS2 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, IHC, IP, WB |
| Conjugate | Unconjugated |
| Purity | Affinity Purified |
| Immunogen | Synthetic peptide taken within amino acid region 220-270 on human Mismatch Repair endonuclease PMS2 protein. |
| Size | 100 µg |
| Storage | -20°C |
| UniProt | P54278 |
About this target
PMS2 Antibody (PMS2-201AP) is an affinity-purified rabbit polyclonal antibody against PMS2. It is listed for ELISA, IHC, IP, WB and reacts with Human, Mouse, Rat. For research use only. Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. Subcellular location: Nucleus.
Documents
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FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.