PMS2 Blocking Peptide
Catalog no. P-PMS2.201 · Research Use Only
$155 per 250 µg. Ships within 2–3 business days from the U.S.
P-PMS2.201 — affinity-purified Rabbit antibody against PMS2. Validated for Immunodepletion, Immunocompetition.
Specifications
| Catalog number | P-PMS2.201 |
|---|---|
| Target | PMS2 |
| Applications | Immunodepletion, Immunocompetition |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide taken within amino acid region 220-270 on human Mismatch Repair endonuclease PMS2 protein. |
| Size | 250 µg |
| Storage | -20°C |
| UniProt | P54278 |
About this target
PMS2 Blocking Peptide is the antigenic blocking peptide for the PMS2 antibody PMS2-201AP. Pre-incubating the antibody with the peptide competes away specific binding, which helps confirm that a signal comes from the intended target. Supplied at 250 µg, for research use only. Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. Subcellular location: Nucleus.
Documents
Related products
- PMS2 Blocking Peptide (P-PMS2.212)
- PMS2 Positive Control (PC-PMS2)
- PMS2 Antibody (PMS2-201AP)
- PMS2 Antibody (PMS2-212AP)
- PMS2 Antibody BIOTIN (PMS2.201-BIOTIN)
- PMS2 Antibody FITC (PMS2.201-FITC)
- PMS2 Antibody BIOTIN (PMS2.212-BIOTIN)
- PMS2 Antibody FITC (PMS2.212-FITC)
FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.