PMS2 Antibody FITC
Catalog no. PMS2.201-FITC · Research Use Only
$375 per 100 µg. Ships within 2–3 business days from the U.S.
PMS2.201-FITC — affinity purified Rabbit antibody against PMS2. Validated for ELISA, WB. Reacts with Human, Mouse, Rat.
Specifications
| Catalog number | PMS2.201-FITC |
|---|---|
| Target | PMS2 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Conjugate | FITC |
| Purity | Affinity Purified |
| Immunogen | Synthetic peptide taken within amino acid region 220-270 on human Mismatch Repair endonuclease PMS2 protein. |
| Size | 100 µg |
| Storage | -20°C |
| UniProt | P54278 |
About this target
PMS2 Antibody FITC is the FITC-conjugated version of the PMS2 antibody PMS2-201AP, an affinity-purified rabbit polyclonal used in ELISA, WB and reactive with Human, Mouse, Rat. The conjugate removes the need for a labeled secondary antibody in direct detection. For research use only. Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. Subcellular location: Nucleus.
Documents
Related products
- PMS2 Blocking Peptide (P-PMS2.201)
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- PMS2 Antibody FITC (PMS2.212-FITC)
FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.