CXCR2 Blocking Peptide
Catalog no. P-CXCR2-221 · Research Use Only
$155 per 250 µg. Ships within 2–3 business days from the U.S.
P-CXCR2-221 — affinity-purified Rabbit antibody against CXCR2. Validated for Immunodepletion, Immunocompetition.
Specifications
| Catalog number | P-CXCR2-221 |
|---|---|
| Target | CXCR2 |
| Applications | Immunodepletion, Immunocompetition |
| Conjugate | Unconjugated |
| Immunogen | Synthetic peptide corresponding to amino acids within region 300-352 on mouse C-X-C Chemokine Receptot type 2. |
| Size | 250 µg |
| Storage | -20°C |
| UniProt | P35343 |
About this target
CXCR2 Blocking Peptide is the antigenic blocking peptide for the CXCR2 antibody CXCR2-201AP. Pre-incubating the antibody with the peptide competes away specific binding, which helps confirm that a signal comes from the intended target. Supplied at 250 µg, for research use only. Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. Signals intravascular neutrophil chemotaxis to the injury site. Subcellular location: Cell membrane; Multi-pass membrane protein.
Documents
Related products
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FabGennix International, Inc., 9191 Kyser Way, Frisco, TX 75033. For research use only. Not for diagnostic or therapeutic use.