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General Information
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Product
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ABL1 Antibody
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Description
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Affinity Purified Tyrosine-protein kinase ABL1 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 990-1130 of human Isoform IB of Tyorsine-protein kinase ABL1 protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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| Immunohistochemistry |
1:50-1:100 |
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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P00519
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Overview
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Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration.
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Molecular Function
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Kinase, Transferase, Tyrosine-protein kinase
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Subcellular Location
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Cytoplasm > cytoskeleton, Nucleus, Mitochondrion
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Expression
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Widely expressed.
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Structure
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Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. Contains 1 proteins kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain.
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Alternative Nomenclature
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Abelson murine leukemia viral oncogene homolog 1 antibody
Abelson tyrosine protein kinase 1 antibody
Abl 1 antibody
ABL antibody
ABL proto oncogene 1 non receptor tyrosine kinase antibody
ABL1 antibody
bcr/abl antibody
c abl oncogene 1 receptor tyrosine kinase antibodyJTK7 antibody
p150 antibody
Proto oncogene tyrosine protein kinase ABL1 antibody
Proto-oncogene c-Abl antibody
Tyrosine-protein kinase ABL1 antibody
v abl Abelson murine leukemia viral oncogene homolog 1 antibody
v abl antibody
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ABL1 Antibody BIOTIN
ABL1 Antibody FITC
ABL1 Blocking Peptide
ABL1 Positive Control
