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The cGAS-STING pathway mediates ati-microbial innate immunity by inducting the production of tpe i interferonsand inflammatory cytokines upon recognition of microbial DNA. Recent studies reveal that self-DNA from tumors and by-prodcuts of genomic instablility also activates the cGAS-sting pathway and either promotes or inhiits tuor development (1).
Explore FabGennix's products related to the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. For a limited time, we are also offering a cGAS-STING pathway antibody sampler pack. More information can be found here.
1. Khoo, Li Teng, and Liuh‐Yow Chen. "Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches." EMBO reports 19.12 (2018): e46935.