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General Information
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Product
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CTLA4 Antibody
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Description
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Affinity Purified Cytotoxic T-lymphocyte protein 4 Antibody
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Verified Applications
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ELISA, ICC, IF, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 150-200 on human CTLA4 protein.
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Accession #
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GenBank: AAL07473.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.7 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunocytochemistry
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1:100
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Immunofluorescence
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1:100
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Immunohistochemistry
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1:100
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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P16410
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Overview
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Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family lingands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory correceptor CD28.
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Molecular Function
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Adaptive Immunity
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Subcellular Location
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Cell membrane; Single pass type I membrane protein
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Expression
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Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory correceptor, on the cell surface following activation.
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Structure
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Homodimer; disfulfide-linked
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Alternative Nomenclature
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CD 152 antibody
CD antibody
CD152 antigen antibody
CD152 isoform antibody
Celiac disease 3 antibody
CELIAC3 antibody
CTLA-4 antibody
Cytotoxic T cell associated 4 antibody
Cytotoxic T lymphocyte associated serine esterase 4 antibody
GRD4 antibody
GSE antibody
ICOS antibody
IDDM12 antibody
Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 antibody
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CTLA4 Antibody FITC
CTLA4 Antibody BIOTIN
CTLA4 Blocking Peptide
CTLA4 Positive Control
