Atypical Chemokine Receptor D6 Antibody

General Information

Product

D6 Antibody

Description

Affinity Purified Atypical chemokine receptor 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-378 mouse Atypical chemokine receptor 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O08707

Overview

Controls chemokine levels and localization via high-affinity chemoking binding that is uncoupled from classic liand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.  Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells and is required for immature/mature dendritic cells discrimination.

Molecular Function

Chemokine Receptor activity; Scavenger receptor activity

Subcellular Location

Early endosome; Recycling endosome; Cell membrane; Multi-pass membrane protein

Expression

Endothelial cells lining afferent lympatics in dermis and lymph nodes.  Also found n subcapsular and medullary sinuses, tonsillar lympatic sinuses and lymphatics in mucosa and submucosa of appendix, small intestine, and large intestine.

Structure

C-terminal cytoplasmic tail controls phosphorylation, stability, intracellular trafficking and chemokine scavenging properties.

Alternative Nomenclature

ACKR2 antibody

Atypical chemokine receptor 2 antibody

Chemokine binding protein 2 antibody

Chemokine receptor CCR 10 antibody

Chemokine receptor CCR 9 antibody

CMKBR9 antibody