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General Information
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Product
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AIM2 Antibody
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Description
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Affinity Purified Interferon-inducible protein AIM2 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse
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Immunogen
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Synthetic peptide taken within amino acid region 240-340 on human AIM2 protein.
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Accession #
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NCBI: NP_004824
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.58 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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| Immunohistochemistry |
1:50-1:100 |
| Immunoprecipitation |
1:200 |
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Western Blot
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1:500
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Protein
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Uniprot #
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O14862
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Overview
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Innate immune response recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
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Molecular Function
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Apoptosis, Immunity, Inflammatory response, Innate Immunity
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Expression
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Expressed in spleen, small intestine, peripheral blood leukocytes and testis.
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Structure
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Self-associates; forms homodimers in response to cytosolic dsDNA and the dsDNA serves as oligomerization platform.
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Alternative Nomenclature
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Absent in melanoma 2 antibody
PYHIN4 antibody
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AIM2 Antibody FITC
AIM2 Antibody BIOTIN
AIM2 Blocking Peptide
AIM2 Positive Control
