CD163 Antibody


CD163 Antibody

Product no.: CD163-101AP
$295.00
$265.00


General Information

 

 

Product

 

CD163 Antibody

Description

Affinity Purified CD163 Antibody N-epitope

Verified Applications

ELISA, IHC, IF, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 600-650  on human CD163 protein.

Accession #

GenBank: EAW88662.1


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20C for long term storage


Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunofluorescence 1:100

Immunohistochemistry

1:150

Immunoprecipitation 1:100

Western Blot

1:500


Protein

 

Uniprot #

 

D3DUU0

Overview

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Molecular Function

Scavenger receptor activity

Subcellular Location

Membrane

Expression

Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.

Structure

Interacts with CSNK2B.

Alternative Nomenclature

CD163 antigen antibody

CD163 molecule antibody

Hemoglobin Scavenger Receptor antibody

Macrophage associated antigen antibody

MM130 antibody

Scavenger receptor cysteine rich type 1 protein M130 antibody

sCD163 antibody

Soluble CD163 antibody

   

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
CD163 Antibody FITC CD163 Antibody FITC
CD163.101-FITC $350.00 *
CD163 Antibody BIOTIN CD163 Antibody BIOTIN
CD163.101-BIOTIN $350.00 *
CD163 Blocking Peptide CD163 Blocking Peptide
P-CD163.101 $145.00 *
CD163 Positive Control CD163 Positive Control
PC-CD163 $185.00 *
Display accessory details

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