CD86 Antibody

General Information

Product

CD86 Antibody Affinity Purified

Description

Affinity Purified T-lymphocyte activation antigen CD86 isoform 1 precursor Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 250-329 on human CD86 protein.

Accession #

NCBI:  NP_787058

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000

ELISA

1:20,000

Western Blot

1:500

Protein

Uniprot #

P42081

Overview

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

Molecular Function

Receptor; Adaptive Immunity; Host-virus interaction; Immunity

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Expressed by activated B-lymphocytes and monocytes.

Structure

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.  Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative Nomenclature

Activation B7 2 antigen antibody

B-lymphocyte activation antigen B7-2 antibody

B7 2 antibody

B70 antibody

BU63 antibody

CD 86 antibody

CD28 antigen ligand 2 2 antibody

CLS1 antibody

CTLA 4 counter receptor B7 2 antibody

Early T-cell costimulatory molecule 1 antibody

ETC-1 antibody

FUN 1 antibody

LAB72 antibody

Ly-58 antibody

MB7-2 antibody

Membrane glycoprotein antibody

MGC34413 antibody

T-lymphocyte activation antigen CD86 antibody

TS/A-2 antibody