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General Information
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Product
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CXCR7 Antibody
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Description
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Affinity Purified Chemokine (C-X-C motif) receptor 7 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Monkey, Mouse, Rat
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Immunogen
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Synthetic peptide corresponding to unique amino acid sequence on human CXCR7 protein.
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Accession #
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GenBank: AAH36661
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.68 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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Confocal Microscopy
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1:250
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Immunocytochemistry
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1:250
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Immunofluorescence
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1:250
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Immunohistochemistry
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1:250
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Immunoprecipitation
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1:250
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Western Blot
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1:500
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Protein
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Uniprot #
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P25106
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Overview
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Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival.
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Molecular Function
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Cell adhesion, Host-virus interaction
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Subcellular Location
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Cell membrane; Multi-pass membrane protein. Cytoplasm › perinuclear region. Early endosome. Recycling endosome
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Expression
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Expressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue.
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Structure
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Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2.
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Alternative Nomenclature
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ACKR3 antibody
atypical chemokine receptor 3 antibody
C X C chemokine receptor type 7 antibody
Chemokine orphan receptor 1 antibody
CMKOR1 antibody
CXC R7 antibody
G protein coupled receptor 159 antibody
G protein coupled receptor RDC1 homolog antibody
GPR159 antibody
GPRN1 antibody
RDC 1 antibody
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CXCR7 Antibody FITC
CXCR7 Antibody BIOTIN
CXCR7 Blocking Peptide
CXCR7 Positive Control
