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General Information
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Product
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Deformed Epidermal Autoregulatory Factor 1 Antibody
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Description
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Affinity Purified Deformed epidermal autoregulatory factor 1 homolog Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Mouse, Rat
Predicted: Human
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Immunogen
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Synthetic peptide taken within amino acid region 500-565 on mouse Deformed epidermal autoregulatory factor 1 homolog protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5-1.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunocytochemistry
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1:50-1:150
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Immunohistochemistry
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1:50-1:150
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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Q9Z1T5
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Overview
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Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3.
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Molecular Function
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DNA binding, metal ion binding, transcription factor activity, sequence-specific DNA binding
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Subcellular Location
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Cytoplasm, Nucleus, Secreted
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Expression
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Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells. Expression in pancreatic lymph nodes of patients with type 1 diabetes is 20 times higher than in healthy controls. Highly expressed in fetal and adult brain.
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Structure
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Zinc-finger
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Alternative Nomenclature
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Deaf1 antibody
DEAF1 transcription factor antibody
Deformed epidermal autoregulatory factor 1 homolog antibody
Nuclear DEA1 related transcriptional regulator antibody
NUDR antibody
SPN antibody
Suppressin antibody
Zinc finger MYND domain containing protein 5 antibody
ZMYND5 antibody
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Deformed Epidermal Autoregulatory Factor 1 Antibody BIOTIN
Deformed Epidermal Autoregulatory Factor 1 Antibody FITC
Deformed Epidermal Autoregulatory Factor 1 Blocking Peptide
Deformed Epidermal Autoregulatory Factor 1 Positive Control
