HIPK2 Antibody

Product no.: HIPK2-201AP

$285.00

Description

General Information
Product	HIPK2 Antibody
Description	Affinity Purified Homeodomain-interacting protein kinase 2 Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 1150-1198 on human Homeodomain-interacting protein kinase 2 protein.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5-1.5 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Purification Method	Immobilized antigen affinity chromatography
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:50,000
Immunoprecipitation	1:200
Western Blot	1:2,500-1:5,000
Protein
Uniprot #	Q9H2X6
Overview	Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A.
Molecular Function	ATP binding protein kinase activity protein serine/threonine kinase activity RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity SMAD binding transcription corepressor activity virion binding
Subcellular Location	Nucleus, PML body, Cytoplasm
Expression	Highly expressed in heart, muscle and kidney. Weakly expressed in a ubiquitous way. Down-regulated in several thyroid and breast tumors.
Alternative Nomenclature	HIPK 2 antibody Homeodomain interacting protein kinase 2 antibody Nbak1 antibody Nuclear body-associated kinase 1 antibody PRO0593 antibody Sialophorin tail-associated nuclear serine/threonine-protein kinase antibody Stank antibody

Protein information supplied by UniProt.