IRF8 Antibody

Product no.: IRF8M-101AP

$285.00

Description

General Information
Product	IRF8 Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 350-400 on mouse Interferon Regulatory Factor 8 protein.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5-1.5 µg/µl in antibody stabilization buffer
Immunoglobulin	IgG
Form	Affinity Purified
Purification Method	Immobilized antigen affinity chromatography
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:50,000
Immunoprecipitation	1:200
Immunohistochemistry	1:50-1:150
Western Blot	1:2,500-1:5,000
Protein
Uniprot #	P23611
Overview	Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (PubMed:22992524).
Molecular Function	DNA binding DNA binding transcription factor activity RNA polymerase II proximal promoter sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Subcellular Location	Nucleus, cytoplasm
Expression	Predominantly in lymphoid tissues.
Structure	Belongs to the IRF family.
Alternative Nomenclature	H ICSBP antibody HICSBP antibody ICSBP 1 antibody Interferon consensus sequence binding protein 1 antibody Interferon regulatory factor 8 antibody IRF 8 antibody MYLS antibody

Protein information supplied by UniProt.