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General Information
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Product
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EGR2 Antibody
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Description
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Affinity Purified E3 SUMO-protein ligase EGR2 / KROX20 Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 60-150 on mouse E3 SUMO-protein ligase EGR2.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5-1.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunoprecipitation
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1:200
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Western Blot
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1:2,500-1:5,000
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Protein
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Uniprot #
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P08152
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Overview
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Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.
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Molecular Function
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chromatin binding
DNA binding
HMG box domain binding
ligase activity
metal ion binding
RNA polymerase II activating transcription factor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activ
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Subcellular Location
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Nucleus
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Expression
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Expressed in mammary tumors (at protein level). Expressed mainly in adult thymus and embryonic nervous system.
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Structure
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Belongs to the EGR C2H2-type zinc-finger protein family.
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Alternative Nomenclature
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AT591 antibody
CMT1D antibody
CMT4E antibody
E3 SUMO-protein ligase EGR2 antibody
Early growth response 2 antibody
EGR-2 antibody
FLJ14547 antibody
KROX 20 Drosophila homolog antibody
KROX20 antibody
Zinc finger protein Krox-20 antibody
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EGR2 Antibody BIOTIN
EGR2 Antibody FITC
EGR2 Blocking Peptide
EGR2 Positive Control
