MAPK13 Antibody

Product no.: MAPK13-101Y

$285.00

Description

General Information
Product	MAPK13 Antibody
Description	Affinity Purified Mitogen-activated protein kinase 13 Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Chicken
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 310-360 on human Mitogen-activated protein kinase 13.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.5 µg/µl in antibody stabilization buffer
Immunoglobulin	IgY
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
ELISA	1:10,000
Immunohistochemistry	1:50-1:150
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	O15264
Overview	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms.
Molecular Function	Kinase, Serine/threonine-protein kinase, Transferase
Subcellular Location	Cytosol
Expression	Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.
Structure	The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
Alternative Nomenclature	MAP kinase 13 antibody MAPK 13 antibody Mitogen activated protein kinase 13 antibody p38 delta antibody PRKM13 antibody SAPK 4 antibody Stress activated protein kinase 4 antibody

Protein information supplied by UniProt