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General Information
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Product
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MAPK9 Antibody
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Description
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Affinity Purified Mitogen-activated protein kinase 9 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Chicken
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 370-420 on human Mitogen-activated protein kinase 9.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgY
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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| Immunohistochemistry |
1:50-1:100 |
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Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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P45984
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Overview
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Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity.
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Molecular Function
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Kinase, Serine/threonine-protein kinase, Transferase
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Subcellular Location
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Cytoplasm, Nucleus
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Structure
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Interacts with MECOM and DCLK2. Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with NFATC4. Interacts with ATF7; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN. Interacts with BCL10. Interacts with CTNNB1 and GSK3B.
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Alternative Nomenclature
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c Jun kinase 2 antibody
JNK 55 antibody
JNK2 alpha antibody
JNK2 antibody
JNK2 beta antibody
Jun kinase antibody
MAP kinase 9 antibody
P54a antibody
p54aSAPK antibody
PRKM9 antibody
SAPK alpha antibody
Stress activated protein kinase 1a antibody
Stress-activated protein kinase JNK2 antibody
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MAPK9 Antibody BIOTIN
MAPK9 Antibody FITC
MAPK9 Blocking Peptide
MAPK9 Positive Control
