General Information
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Product
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Mitofusin 2 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 543-593 on human Mitofusin 2 protein.
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Accession #
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NCBI: NP_055689
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.6 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunohistochemistry
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1:100
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Immunoprecipitation |
1:200 |
Western Blot
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1:500
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Protein
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Uniprot #
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O95140
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Overview
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Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
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Molecular Function
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Hydrolase; GTP-binding, Nucleotide binding
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Subcellular Location
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Mitochondrion outer membrane; Multi-pass membrane protein
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Expression
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Ubiquitous; expressed at low level. Highly expressed in heart and kidney.
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Structure
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Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA famil. Mitofusin subfamily. Contains 1 dynamin-type G (guanine nucleotide-binding) domain.
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Alternative Nomenclature
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CMT2A antibody
CMT2A2 antibody
CPRP 1 antibody
EC 3.6.5.- antibody
Fzo antibody
HSG antibody
hyperplasia suppressor gene antibody
Hypertension related protein 1 antibody
KIAA0214 antibody
MARF antibody
MFN 2 antibody
Mitochondrial assembly regulatory factor antibody
Mitofusin-2 antibody
Transmembrane GTPase MFN2 antibody
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