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General Information
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Product
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MRAP2 Antibody Affinity Purified
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Description
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Affinity Purified Melanocortin-2 receptor accessory protein Antibody N-epitope
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Verified Applications
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CM, ELISA, ICC, IF, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Mouse, Rat
Predicted: Human
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Immunogen
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Synthetic peptide taken within amino acid region 1-50 on mouse Melanocortin-2 receptor accessory protein.
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Accession #
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NCBI: AY079153
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.60-0.61 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Determinant
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N-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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DOT blot
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1:10,000
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ELISA
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1:10,000
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Immunofluorescence
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1:200
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Immunohistochemistry
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1:200
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Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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Q9D159
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Overview
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Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity).
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Molecular Function
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Brown fat cell differentiation; Positive regulation of cAMP biosynthetic process; Protein localization to cell surface
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Subcellular Location
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Single-pass membrane protein; Endoplasmic Reticulum membrane
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Expression
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Largely restricted to fat tissues. Predominantly expressed in mouse epididymal (white adipose tissue) and interscapular (brown adipose tissue) fat pads. Expression is weak or absent in lung, spleen, intestine, kidney, heart and skeletal muscle.
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Structure
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Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP2. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R (By similarity).
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Alternative Nomenclature
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bA51G5.2 antibody
BMIQ18 antibody
C6orf117 antibody
MC2R accessory protein 2 antibody
Melanocortin-2 receptor accessory protein 2 antibody
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MRAP2 Antibody FITC
MRAP2 Antibody BIOTIN
MRAP2 Blocking Peptide
MRAP2 Positive Control
