MRAP2 Antibody

Product no.: MRAP2-201AP

$285.00

Description

General Information
Product	MRAP2 Antibody Affinity Purified
Description	Affinity Purified Melanocortin-2 receptor accessory protein Antibody N-epitope
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Mouse, Rat Predicted: Human
Immunogen	Synthetic peptide taken within amino acid region 1-50 on mouse Melanocortin-2 receptor accessory protein.
Accession #	NCBI: AY079153
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.60-0.61 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Determinant	N-epitope
Storage	-20⁰C for long term storage
Application Protocol
DOT blot	1:10,000
ELISA	1:10,000
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	Q9D159
Overview	Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity).
Molecular Function	Brown fat cell differentiation; Positive regulation of cAMP biosynthetic process; Protein localization to cell surface
Subcellular Location	Single-pass membrane protein; Endoplasmic Reticulum membrane
Expression	Largely restricted to fat tissues. Predominantly expressed in mouse epididymal (white adipose tissue) and interscapular (brown adipose tissue) fat pads. Expression is weak or absent in lung, spleen, intestine, kidney, heart and skeletal muscle.
Structure	Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP2. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R (By similarity).
Alternative Nomenclature	bA51G5.2 antibody BMIQ18 antibody C6orf117 antibody MC2R accessory protein 2 antibody Melanocortin-2 receptor accessory protein 2 antibody

Protein information supplied by UniProt