Apelin Blocking Peptide

General Information

Product

Apelin Peptide

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide taken within amino acid region 25-77 on human Apelin protein.

Accession #

NCBI:  NP_059109

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

Q9ULZ1

Overview

Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.

Molecular Function

G-protein coupled receptor binding, receptor binding

Subcellular Location

Secreted

Expression

Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk.

Structure

Belongs to the apelin family.

Alternative Nomenclature

AGTRL1 ligand antibody

APEL antibody

Apelin-13 antibody

APJ endogenous ligand antibody

Apln antibody

XNPEP2 antibody