General Information
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Product
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DYRK2 Peptide
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Description
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Antigenic Blocking Peptide Dual specificity tyrosine-phosphorylation-regulated kinase 2
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 550-601 on human Dual specificity tyrosine-phosphorylation-regulated kinase 2.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q92630
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Overview
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Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity.
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Molecular Function
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Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
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Subcellular Location
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Cytoplasm, Nucleus
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Expression
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Testis, after the onset of spermatogenesis.
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Structure
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Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
Contains 1 protein kinase domain.
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Alternative Nomenclature
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AOMS3 antibody
Dual specificity tyrosine (Y) phosphorylation regulated kinase 1B antibody
DYR1A antibody
DYR1B antibody
Minibrain-related kinase antibody
MIRK antibody
Mirk protein kinase antibody
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